Review
Copyright ©2011 Baishideng Publishing Group Co.
World J Clin Oncol. Aug 10, 2011; 2(8): 311-325
Published online Aug 10, 2011. doi: 10.5306/wjco.v2.i8.311
Figure 2
Figure 2 Domain structure and phylogenetic tree of human dickkopf proteins. A: Each dickkopf (DKK) contains two cysteine-rich domains, each of which is separated by a linker region of various lengths. The amino-terminal cysteine-rich domain (Cys-1) domains are unique to each DKK, whereas the carboxyl-terminal cysteine-rich domain (Cys-2) domains are conserved among all members of the DKK family; B: Phylogenetic tree of the DKK proteins. Amino acid sequences were aligned by the Clustal W program, and the phylogenetic tree was constructed by the neighbour joining method. The scale bar indicates the estimated number of substitutions per 50 amino acids. SP: Signal peptide.