Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies

Table 1 The main results of CD105 and VEGF studies

Study	n	High levels of CD105 were associated with	High levels of VEGF were associated with
Barozzi et al[7]	101	M1	M1
Saad et al[25]	150	M1, N1 and angiolymphatic invasion	N1, angiolymphatic and depth of invasion
De Vita et al [37]	81	NE	NCs (serum levels)
Cascinu et al[38]	121	NE	RR
Myśliwiec et al[29]	48	M1	Colorectal cancer patients (plasma levels)
Li et al[48]	111	Dukes' stages and survival	NE
Takahashi et al[49]	34	M1	NE
Liang et al[51]	114	NE	N1, TNM staging and poor prognosis
Zheng et al[52]	97	NE	Poorly differentiated adenocarcinoma
Cressey et al [31]	76	NE	TNM
Cao et al[53]	71	NE	N1, M1, TNM, and OS
Miyazaki et al[58]	127	NE	RR, DF, OS (plasma levels)

DF: Disease-free; M1: Positive distant metastasis; N1: Positive lymph node metastasis; NCs: Non-curative surgery; NE: Not evaluated; OS: Overall survival; RR: Recurrence rate