Review of the treatment of metastatic non small cell lung carcinoma: A practical approach

Table 3 Selected trials of erlotinib and bevacizumab

Study	Phase	n	Eligibility	Regimen	Line of therapy	Primary endpoint
PASSPORT (AVF3752g)	II	110	Previously treated or untreated non-squamous NSCLC with treated CNS metastases	Chemo or erlotinib followed by bev	First/second	Grade ≥ 2 symptomatic CNS haemorrhage
BRAIN (AVF21823)	II	115	Stage IV non-squamous NSCLC with asymptomatic brain metastases in first and second line	First line: bev + carbo/pac	First/second	PFS
				Second line: bev + erlotinib
EAGLES	II	78	Patients aged > 70 yr without important comorbidities	Bev + gem or bev + gem/cis	First	PFS at 6 mo
ML21896	II	~250	Patients aged ≥ 65 yr with advanced metastatic or recurrent non-squamous NSCLC	Bev + pem or bev + pem/carbo	First	Proof of non-inferiority of bev + pem
BRIDGE (AVF2744g)	I/II	40	Previously untreated squamous NSCLC	Bev + carbo/pac	First	Grade ≥ 3 pulmonary haemorrhage
ABIGAIL (BO21015)	II	~300	Locally advanced, metastatic or recurrent non-squamous NSCLC	Bev + carbo/gem or carbo/pac	First	Correlation of biomarkers with response
MIMEB (ML21803)	II	40	Histologically confirmed advanced non-squamous NSCLC stage IIIB/IV	Bev + erlotinib	First	Evaluate accuracy of FDG-/FLT-PET and DCE-MRI for early prediction of non-progression
EURTAC	III	146	EGFR mutation-positive NSCLC	Erlotinib	First	PFS in patients with
SATURN (BO18192)	III	1949	Previously untreated advanced NSCLC	Erlotinib	First	PFS in all patients and in patients with EGFR IHC+ tumours
RADIANT		945	Advanced NSCLC	Erlotinib vs placebo	Adjuvant	DFS
FASTACT-2	III	450	Asian patients with previously untreated advanced NSCLC	Erlotinib + chemo vs placebo + chemo	First line	PFS
ATLAS (AVF3671f)	III	1150	Previously untreated advanced NSCLC	Bev + carbo/pac, gem/cis or carbo/doc)	First line maintenance	PFS
				Non-progressing patients randomized (1:1) to bev + erlotinib or bev + placebo
TARGET	II	428	EGFR mutation-positive NSCLC	Erlotinib	First	PFS
TORCH	III	900	Previously untreated advanced NSCLC	First-line erlotinib second-line gem/cis vs first-line gem/cis second-line erlotinib	First/second	OS

NSCLC: Non-small cell lung cancer; CNS: Central nervous system; bev: Bevacizumab; carbo: Carboplatin; pac: Paclitaxel; PFS: Progression-free survival; gem: Gemcitabine; cis: Cisplatin; pem: Pemetrexed; FDG: [18F]-2-fluoro-deoxy-D-glucose; FLT: F-fluorodeoxythymidine; PET: Positron emission tomography; DCE-MRI: Dynamic contrast-enhanced magnetic resonance imaging; EGFR: Epidermal growth factor receptor; IHC: Immunohistochemistry; DFS: Disease-free survival; chemo: Chemotherapy; doc: Docetaxel; OS: Overall survival.