Automation of immunohistochemical evaluation in breast cancer using image analysis

Table 5 Spearman correlation coefficient (95% confidence interval) of the different evaluations

	Expert vs automated analysis1	Expert vs pathologist2	Pathologist reading 1 vs pathologist reading 23
ER expression	0.73 (0.59 to 0.83)	0.53 (0.32 to 0.69)	0.46 (0.24 to 0.64)
PR expression	0.82 (0.73 to 0.90)	0.63 (0.45 to 0.76)	0.66 (0.49 to 0.78)
HER-2/neu expression	0.92 (0.88 to 0.96)	0.68 (0.52 to 0.80)	0.70 (0.54 to 0.81)

¹Represents the correlation of the automated analysis with the expert’s evaluation;

²Represents the correlation between two pathologists;

³Represents the correlation between readings by the same pathologists taken at different time periods. It can be seen that the Spearman correlation coefficients for evaluations by automated analysis are better for all receptor expressions.