Automation of immunohistochemical evaluation in breast cancer using image analysis

Table 4 Results of the classification of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression images

	True positive	True negative	False positive	False negative	Sensitivity (%)	Specificity (%)	PPV1 (%)	NPV2 (%)
ER expression	14	38	8	0	100	82.6	63.6	100
PR expression	10	43	7	0	100	86.0	58.8	100
HER-2/neu expression	46	9	5	0	100	64.3	90.2	100

¹PPV: Positive predictive value;

²NPV: Negative predictive value. It can be seen that the sensitivity has been maintained at 100%. The specificity of the evaluations for ER and PR is good. The specificity of HER-2/neu expression is comparatively less than the ER and PR expression evaluations. ER: Estrogen receptor; PR: Progesterone receptor; HER-2/neu: Human epidermal growth factor receptor-2.