Targeting metastatic upper gastrointestinal adenocarcinomas

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Mar 10, 2011 (publication date) through Dec 26, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Mar 10, 2011; 2(3): 135-149
Published online Mar 10, 2011. doi: 10.5306/wjco.v2.i3.135

Table 1 Human epidermal growth factor receptor family inhibitors in upper gastrointestinal malignancies

Drug	Mechanism of action	Applicable tumor site(s)
Cetuximab	Intravenous IgG1 monoclonal antibody inhibiting the extracellular domain of EGFR thereby preventing receptor activation	Gastric
		Biliary tract
		Pancreas
Erlotinib	Oral intracellular small molecule selective EGFR TKI	Biliary tract
Erlotinib	Oral intracellular small molecule selective EGFR TKI	Pancreas
Trastuzumab	Intravenous recombinant humanized anti-HER2 monoclonal antibody directed against the HER-2 extracellular domain	Gastric
Lapatinib	Oral TKI targeting EGFR and HER-2	Gastric

EGFR: Endothelial growth factor receptor; TKI: Tyrosine kinase inhibitor; HER: Human epidermal growth factor receptor.

Citation: Spratlin JL, Chu Q, Koski S, King K, Mulder K. Targeting metastatic upper gastrointestinal adenocarcinomas. World J Clin Oncol 2011; 2(3): 135-149
URL: https://www.wjgnet.com/2218-4333/full/v2/i3/135.htm
DOI: https://dx.doi.org/10.5306/wjco.v2.i3.135