Exploiting the homologous recombination DNA repair network for targeted cancer therapy

doi:10.5306/wjco.v2.i2.73

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Feb 10, 2011; 2(2): 73-79
Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.73

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Figure 4 Mechanism of synthetic lethality interaction between poly (ADP-ribose) polymerase inhibitors and homologous recombination repair deficiency. DSB: Double strand break; SSB: Single strand break; HR: Homologous recombination; RPA: DNA replication protein A; BRCA: Breast cancer susceptibility protein; PARP: Poly (ADP-ribose) polymerase.

Citation: Peng G, Lin SY. Exploiting the homologous recombination DNA repair network for targeted cancer therapy. World J Clin Oncol 2011; 2(2): 73-79
URL: https://www.wjgnet.com/2218-4333/full/v2/i2/73.htm
DOI: https://dx.doi.org/10.5306/wjco.v2.i2.73