Exploiting the homologous recombination DNA repair network for targeted cancer therapy

doi:10.5306/wjco.v2.i2.73

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Feb 10, 2011 (publication date) through Jul 29, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Feb 10, 2011; 2(2): 73-79
Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.73

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Figure 3 Double strand break repair pathways and the points of action of cancer treatment drugs. HR: Homologous recombination; NHEJ: Non-homologous end joining; DSB: Double strand break; RPA: DNA replication protein A; RAD51: DNA repair protein RAD51 homolog 1; MRE11: Meiotic recombination 11 Homolog 1; NBS1: Nijmegen B breakage syndrome 1; BRCA: Breast cancer susceptibility protein; XRCC: X-ray repair cross-complementing protein.

Citation: Peng G, Lin SY. Exploiting the homologous recombination DNA repair network for targeted cancer therapy. World J Clin Oncol 2011; 2(2): 73-79
URL: https://www.wjgnet.com/2218-4333/full/v2/i2/73.htm
DOI: https://dx.doi.org/10.5306/wjco.v2.i2.73