Oncogenic activity of MCM7 transforming cluster

Figure 1 Diagram of miniature chromosome maintenance 7 oncogenic signaling. Fifteen exons and miR106b-25 oncogenic miRNA cluster of miniature chromosome maintenance (MCM) 7 genome were transcribed into MCM7 mRNA and miRNA 106b, 93 and 25. Two-prong pathways were directed at promoting DNA replication: degradation of crucial tumor suppressor genes p21 and pTEN mRNA by the miR106b-25 cluster, and increased DNA replication licensing by MCM7 protein. Androgen receptor (AR) promotes DNA replication by enhancing MCM7 replication licensing activity. Integrin α7 inhibits DNA replication through inhibition of MCM7 activity. M7: MCM7; M6: MCM6; M5: MCM5; M4: MCM4; M3: MCM3; M2: MCM2; ITGA7: integrin α7; ILK: Integrin-linked kinase; ORC: Origin of replication complex; Rb: Retinoblastoma.