Locally advanced nasopharyngeal carcinoma: Current and emerging treatment strategies

Table 2 Chemo-radiation trials

Trial	Phase	Pts	Study design	Main end-point	Results
Lin JC et al[4]	III	284	Exclusive RT alone vs cDDP-5FU + RT	5-year DFS	Experimental arm better (P < 0.0012)
Chan AT et al[5]	III	350	Exclusive RT alone vs cDDP-5FU + RT	2-year PFS	Experimental arm better (P < 0.016)
Zhang L et al[12]	III(m)	1608	Exclusive RT alone vs cDDP based CT + RT	5-year OS	Experimental arm better (P < 0.001)
Yang AK et al[13]	III(m)	1993	Exclusive RT alone vs cDDP based CT + RT	5-year OS	Experimental arm better (P < 0.05)
Lu H et al[17]	II	22	IMRT + cDDP	1 year OS	96%
Ekenel M et al[34]	II	100	IMRT+ cDDP-Cet	ORR	100%

RT: Radiotherapy; IMRT: Intensity modulated RT; CT: Comptued tomography; ORR: Overall response rate; DFS: Disease-free survival.