Candida albicans and colorectal cancer: A paradoxical role revealed through metabolite profiling and prognostic modeling

Figure 9 Results of liquid chromatography-mass spectrometry detection of the metabolic mixture of Candida albicans. A: Superimposed total ion chromatogram for negative [neg-quality control (A1)(QC)] and positive(A2) (pos-QC) samples; B: Extracted ion chromatogram paths for blank samples in negative (B1) and positive (B2) modes; C: Correlation analysis of QC samples in negative (C1) and positive (C2) modes; D: Ring graphs representing metabolite classes in negative (D1) and positive (D2) modes; E: Distribution maps of coefficient of variation values for negative (E1) and positive (E2) modes.The volatility or dispersion of the data is similar, resulting in the two pictures being the same; F: Principal component analysis score plots showing quality spectrum data for samples and QC samples in negative (F1) and positive (F2) groups; G: Cluster analysis results for negative (G1) and positive (G2) modes; H: S-plot from OPLS-DA analysis; I: Dynamic distribution of differential metabolite content; J: Validation of the OPLS-DA model; K: Volcano plot illustrating differential metabolites; L: Scatter plot of differential metabolites; M: Sample-level clustering tree, comparing Candida albicans metabolites mixture (A) and the control group (NC).