Candida albicans and colorectal cancer: A paradoxical role revealed through metabolite profiling and prognostic modeling

Figure 7 Effects of Candida albicans metabolic mixture on colorectal cancer cell activity, lipid peroxidation content, invasion, migration, reactive oxygen species content, and mitochondrial membrane potential. A: Candida albicans (C. albicans) metabolite mixture reduced cell viability; B: C. albicans metabolite mixture increased intracellular lipid peroxidation (LPO) levels; C and D: Effects of C. albicans metabolite mixture on cell migration (C) and invasion (D); E and F: Quantified histograms showing effects on cell migration (E) and invasion (F); G-I: Flow cytometry results for reactive oxygen species content. G: HCT-116 cells; H: HT-29 cells; I: NCM-460 cells; J-L: C. albicans metabolite mixture decreased mitochondrial membrane potential. J: HCT-116 cells; K: HT-29 cells; L: Quantitative histogram of mitochondrial membrane potential; M: C. albicans metabolite mixture decreased mitochondrial membrane potential in NCM-460 cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.