Downregulation of huntingtin-associated protein 1 predicts poor prognosis in gastric cancer

Table 3 Cox proportional hazards model of the relationship between individual parameters and overall survival

Variables1	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
HAP1 (low)	2.367 (1.876-4.012)	0.011	1.932 (1.142-2.867)	0.029
Age (≥ 55 years)	1.358 (0.768-1.152)	0.934
Sex (female)	0.736 (0.864-1.784)	0.869
Tumor size (≥ 3 cm)	0.805 (0.653-1.251)	0.211
Differentiation (low)	0.854 (0.671-1.126)	0.217
Clinical stage (advanced)	2.675 (1.765-3.467)	0.012	1.878 (1.342-3.247)	0.014
Lymph metastases (yes)	2.348 (1.854-2.637)	0.031	1.641 (0.856-2.536)	0.091
LNR (≥ 27)	0.843 (0.743-1.987)	0.451
Remote metastasis (yes)	2.986 (1.897-4.567)	0.009	2.657 (1.564-3.782)	0.012
Tumor location (distal)	2.283 (1.891-3.147)	0.034	2.154 (1.965-3.012)	0.061
Serosal invasion (yes)	1.786 (1.056-2.435)	0.091

¹Variables in parentheses are the reference.

HR: Hazard ratio; CI: Confidence interval; LNR: Lymph node ratio.