Prognostic value of the preoperative systemic immune-inflammation nutritional index in patients with gastric cancer

Table 2 Univariate and multivariate Cox regression analysis of the associations between clinical parameters and overall survival in patients with gastric cancer, n (%)

Variable		n	HR (univariate analysis)	HR (multivariate analysis)
SIINI	mean ± SD	114.5 ± 184.3	1.00 (1.00-1.00, P = 0.356)
Gender	Female	260 (32.4)
	Male	543 (67.6)	1.00 (0.77-1.30, P = 0.993)
Age	0-51	306 (38.1)
	52-62	267 (33.3)	1.19 (0.88-1.60, P = 0.267)	1.04 (0.75-1.43, P = 0.833)
	≥ 63	230 (28.6)	1.31 (0.97-1.77, P = 0.074)	1.27 (0.92-1.76, P = 0.145)
Weight ratio	Decrease	246 (30.6)
	Stay	381 (47.4)	1.08 (0.82-1.42, P = 0.595)	0.93 (0.68-1.27, P = 0.655)
	Increase	176 (21.9)	0.69 (0.48-1.01, P = 0.054)	0.81 (0.49-1.36, P = 0.431)
History of stomach	None/unknown	710 (88.4)
	Yes	93 (11.6)	1.32 (0.92-1.89, P = 0.133)	1.03 (0.70-1.53, P = 0.874)
History of surgery	No	797 (99.3)
	Yes	6 (0.7)	3.97 (1.27-12.42, P = 0.018)	3.49 (1.02-11.90, P = 0.046)
CEA	Normal	667 (83.1)
	High	136 (16.9)	1.36 (1.00-1.85, P = 0.051)	0.76 (0.54-1.06, P = 0.104)
CA125	Normal	741 (92.3)
	High	62 (7.7)	2.94 (2.01-4.28, P < 0.001)	1.74 (1.14-2.65, P = 0.010)
CA19-9	Normal	682 (84.9)
	High	121 (15.1)	2.28 (1.70-3.04, P < 0.001)	1.60 (1.18-2.16, P = 0.003)
CA153	Normal	778 (96.9)
	High	25 (3.1)	1.15 (0.57-2.32, P = 0.701)
AFP	Normal	778 (96.9)
	High	25 (3.1)	0.88 (0.42-1.87, P = 0.746)
Pre-tissue	Adenocarcinoma	779 (97.0)
	Other/unknown	24 (3.0)	1.37 (0.68-2.76, P = 0.384)
TNM	Early stage	104 (13.0)
	Interim stage	264 (32.9)	1.89 (1.15-3.12, P = 0.013)	0.98 (0.58-1.67, P = 0.949)
	Advanced stage	435 (54.2)	2.48 (1.54-4.00, P < 0.001)	1.03 (0.61-1.72, P = 0.925)
Surgery way	Radical operation	725 (90.3)
	Non-radical surgery	78 (9.7)	3.31 (2.32-4.72, P < 0.001)	1.56 (0.86-2.84, P = 0.143)
Surgery method	Open heart surgery	289 (36.0)
	Laparoscopic surgery	514 (64.0)	1.05 (0.81-1.37, P = 0.702)
Complication	No	687 (85.6)
	Yes	116 (14.4)	1.49 (1.08-2.06, P = 0.015)	1.61 (1.14-2.26, P = 0.006)
Tumor location	Upper/central	232 (28.9)
	Lower section	571 (71.1)	0.79 (0.61-1.02, P = 0.073)	1.14 (0.82-1.59, P = 0.446)
Serous infiltration	No/suspected tumour infiltration	239 (29.8)
	Tumour infiltration	564 (70.2)	2.84 (2.03-3.97, P < 0.001)	1.35 (0.94-1.95, P = 0.105)
Gastric resection scope	Total gastrectomy	196 (24.4)
	Partial gastrectomy	607 (75.6)	0.61 (0.46-0.79, P < 0.001)	0.71 (0.50-1.01, P = 0.058)
Clinical staging	I	143 (17.8)
	II	140 (17.4)	5.95 (2.49-14.24, P < 0.001)	3.69 (1.50-9.06, P = 0.004)
	III	416 (51.8)	12.28 (5.44-27.75, P < 0.001)	6.29 (2.67-14.86, P < 0.001)
	IV	104 (13.0)	29.69 (12.73-69.25, P < 0.001)	10.24 (3.83-27.38, P < 0.001)
Peritoneal metastasis	No	695 (86.6)
	Yes	108 (13.4)	8.06 (6.20-10.48, P < 0.001)	6.06 (4.60-7.98, P < 0.001)
Hb level	Normal	441 (54.9)
	Low	346 (43.1)	1.13 (0.89-1.45, P = 0.317)
	High	16 (2.0)	0.52 (0.16-1.62, P = 0.256)
PA	Normal	464 (57.8)
	Low	333 (41.5)
	High	6 (0.7)
ALB	Normal	627 (78.1)
	Low	166 (20.7)	1.26 (0.95-1.68, P = 0.108)	0.94 (0.67-1.31, P = 0.704)
	High	10 (1.2)	1.70 (0.63-4.57, P = 0.296)	1.45 (0.49-4.31, P = 0.505)
NRI ROC	Low	502 (62.5)
	High	301 (37.5)	0.68 (0.52-0.89, P = 0.005)	1.29 (0.85-1.94, P = 0.229)
PNI ROC	Low	490 (61.0)
	High	313 (39.0)	0.60 (0.46-0.79, P < 0.001)	0.76 (0.54-1.06, P = 0.103)
SIINI ROC	Low	560 (69.7)
	High	243 (30.3)	2.10 (1.64-2.69, P < 0.001)	1.65 (1.26-2.16, P < 0.001)

n = 803, events = 255, Likelihood ratio test = 355.39 on 25 df (P < 0.001). HR: Hazard ratio; NRI: Nutritional risk index; PNI: Prognostic nutritional index; SIINI: Systemic immune-inflammatory-nutritional index; CEA: Carcinoembryonic antigen; CA125: Carbohydrate antigen 125; AFP: Alpha-fetoprotein; TNM: Tumor, node, metastasis; Hb: Haemoglobin; PA: Prealbumin; ALB: Albumin; ROC: Receiver operating characteristic.