Cytochrome P450 3A gene family in gastric cancer: Unveiling diagnostic biomarkers and therapeutic targets for personalized treatment

doi:10.5306/wjco.v16.i4.101548

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Apr 24, 2025 (publication date) through Mar 29, 2025

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Apr 24, 2025; 16(4): 101548
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.101548

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Figure 1 Cytochrome P450 3A enzymes in biological processes. The figure shows the role of cytochrome P450 3A 4/5 in drug metabolism, hormone synthesis/degradation, and cholesterol synthesis, with implications for gastric cancer and therapeutic response. DDI: Drug-drug interaction; DDZI: Drug-disease interaction; CYP3A: Cytochrome P450 3A; Km: Substrate affinity; Kcat: Catalytic efficiency; DHEA: Hormone involved in steroid metabolism; α-naphthoflavone: Cytochrome P450 3A inhibitor; 6β-OH: 6β-hydroxylation.

Citation: Zhu JK, Wang J. Cytochrome P450 3A gene family in gastric cancer: Unveiling diagnostic biomarkers and therapeutic targets for personalized treatment. World J Clin Oncol 2025; 16(4): 101548
URL: https://www.wjgnet.com/2218-4333/full/v16/i4/101548.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i4.101548