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©The Author(s) 2025.
World J Clin Oncol. Mar 24, 2025; 16(3): 101236
Published online Mar 24, 2025. doi: 10.5306/wjco.v16.i3.101236
Published online Mar 24, 2025. doi: 10.5306/wjco.v16.i3.101236
Table 1 World Health Organization 2022 neuroendocrine neoplasm classification for different anatomic sites
| Neuroendocrine neoplasm | Classification | Diagnostic criteria |
| Well-differentiated neuroendocrine neoplasm | Grade 1 (G1) | < 2 mitoses/2 mm2 and/or Ki67 < 3% |
| Grade 2 (G2) | 2-20 mitoses/2 mm2 and/or Ki67 3%-20% | |
| Grade 3 (G3) | > 20 mitoses/2 mm2 and/or Ki67 > 20% | |
| Poorly differentiated neuroendocrine neoplasm | Small cell NEC | > 20 mitoses/2 mm2 and/or Ki67 > 20% (often > 70%), and small cell cytomorphology |
| Large cell NEC | > 20 mitoses/2 mm2 and/or Ki67 > 20% (often > 70%), and large cell cytomorphology |
- Citation: Lv HY, Liu MX, Hong WT, Li XW. Primary hepatic neuroendocrine tumor with a suspicious pulmonary nodule: A case report and literature review. World J Clin Oncol 2025; 16(3): 101236
- URL: https://www.wjgnet.com/2218-4333/full/v16/i3/101236.htm
- DOI: https://dx.doi.org/10.5306/wjco.v16.i3.101236