How to "pick up" colorectal serrated lesions and polyps in daily histopathology practice: From terminologies to diagnostic pitfalls

Figure 1 The modified protocol improved orientation gives pathologists a better representation representation of mucosal architecture and crypt bases. In practice, the specimen envelope can be used in the procedure room during colonoscopy. Firstly, the envelope can be open on the counter top. After performing a polypectomy, the assistant transfers the specimen onto the envelope’s bottom flap, with two pieces of standard adhesive tape attached perpendicularly for easy retrieval. Use a toothpick to gently flatten the specimens, of which the mucosal surface would face up or down. The top flap was then gently folded over the polyp and taped shut. The tape completely encircled the envelope so that tape was affixed to tape. The perpendicular application prevented the specimen from falling out through the sides of the envelope. The corners of the envelope were left untaped, which allowed formalin to enter both the envelope and the specimen. Finally, this complex was placed in a jar of formalin.