Preparation of kakkatin derivatives and their anti-tumor activity

Figure 4 The 6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one induces apoptosis and cycle arrest in hepatocellular carcinoma SMMC-7721 cells. A: Effect of 6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one (HK) on apoptosis of SMMC-7721 cells at 24 hours and 48 hours; B: Quantification of cell apoptosis; C: Effect of HK on SMMC-7721 cell cycle arrest at 24 hours; D: Quantification of cell cycle arrest. ^aP < 0.05; ^bP < 0.01; ^cP < 0.05; ^dP < 0.01; ^eP < 0.05; ^fP < 0.01; ^gP < 0.05; ^hP < 0.01.