Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics

Figure 2 The expression profiles of exosome microRNAs and the selection of interest microRNAs. A-D: The heatmaps and volcano plots of exosome differentially expressed (DE) microRNAs (miRNAs) in poor-responders and good responders pre- neoadjuvant chemotherapy (nCRT) (A and B) and post-nCRT (C and D); E and F: Showed the results of least absolute shrinkage and selection operator regression analysis to identify the exosome hsa-miR-483-5p as candidates for further analysis; G: Shows the cross-group comparison of the expression profiles of hsa-miR-483-5p among the four group. DE: Differentially expressed: NCRT: Neoadjuvant chemotherapy; CAP: College of American Pathologists.