Preparation of kakkatin derivatives and their anti-tumor activity

doi:10.5306/wjco.v15.i8.1078

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Aug 24, 2024 (publication date) through Nov 16, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Aug 24, 2024; 15(8): 1078-1091
Published online Aug 24, 2024. doi: 10.5306/wjco.v15.i8.1078

Table 1 IC₅₀ value of kakkatin and 6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one on tumor Cells (μM)

Drug	SMMC-7721 cells	MGC803 cells
Cisplatin	17.54	20.83
Kakkatin	76.93	38.24
The 6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one	2.50	39.51

Citation: Jiang YY, Dong HH, Zhou WT, Luo JZ, Wei X, Huang YQ. Preparation of kakkatin derivatives and their anti-tumor activity. World J Clin Oncol 2024; 15(8): 1078-1091
URL: https://www.wjgnet.com/2218-4333/full/v15/i8/1078.htm
DOI: https://dx.doi.org/10.5306/wjco.v15.i8.1078