Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics

Table 2 The differential profiles of exosome microRNAs in poor- and good responders

Pre-nCRT (G1 vs G2)				Post-nCRT (G3 vs G4)
miRNAs	Log2FC	P value	Regulation	miRNAs	Log2FC	P value	Regulation
MiR-493-5p	4.64	0.001	Up	MiR-516a-5p	4.74	0.041	Up
MiR-332a-3p	3.85	0.018	Up	MiR-378 g	2.98	0.047	Up
MiR-4324	2.89	0.043	Up	MiR-150-3p	2.38	0.036	Up
MiR-335-3p	2.33	0.001	Up	MiR-483-5p	1.65	0.001	Up
MiR-1303	2.25	0.048	Up	MiR-582-3p	1.16	0.032	Up
MiR-2355-3p	-4.61	0.006	Down	MiR-4497	-4.44	0.026	Down
MiR-184	-4.37	0.027	Down	MiR-935	-3.09	0.029	Down
MiR-5187-5p	-4.33	0.015	Down	MiR-4516	-2.18	0.044	Down
MiR-122-3p	-4.37	0.027	Down	MiR-486-3p	-2.09	0.041	Down
MiR-378a-5p	-3.49	0.001	Down	MiR-651-5p	-1.73	0.032	Down

nCRT: Neoadjuvant chemoradiotherapy; miRNAs: MicroRNAs.