Prognostic value and predictive model of tumor markers in stage I to III gastric cancer patients

Table 2 The association of demographics and clinicopathologic characteristics with four serum tumor markers

Variables	AFP		P value	CEA		P value	CA125		P value	CA19-9		P value
	Positive (n = 1043)	Negative (n = 193)		Positive (n = 904)	Negative (n = 332)		Positive (n = 858)	Negative (n = 378)		Positive (n = 969)	Negative (n = 267)
Gender			0.200			0.072			0.072			0.809
Male	798	139		673	264		663	274		736	201
Female	245	54		231	68		195	104		233	66
Age			0.753			0.002			0.214			0.144
< 65	576	109		526	159		486	199		548	137
≥ 65	467	84		378	173		372	179		421	130
Clinical stage			0.034			0.000			0.000			0.000
I	257	31		263	25		242	46		278	10
II	227	45		208	64		196	76		240	32
III	559	117		433	243		420	256		451	225
T stage			0.855			0.000			0.000			0.000
T1	193	31		208	16		181	43		214	10
T2	108	19		104	23		110	17		121	6
T3	146	28		116	58		109	65		128	46
T4	596	115		476	235		458	253		506	205
N stage			0.005			0.000			0.000			0.000
N0	446	58		430	74		392	112		462	42
N1	171	32		150	53		145	58		166	37
N2	185	42		151	76		149	78		152	75
N3	241	61		173	129		172	130		189	113
Tumor location			0.082			0.000			0.221			0.041
Cardia	537	96		433	200		444	189		485	148
Gastric body	191	48		182	57		155	84		182	57
Antrum of stomach	315	49		289	75		259	105		302	62
Pathological type			1.000			0.324			0.417			0.045
Adenocarcinoma	985	183		858	310		814	354		919	249
Other	58	10		46	22		44	24		50	18
Degree of differentiation			0.606			0.049			0.014			0.002
Well, high, medium	308	53		278	83		269	92		303	58
Moderate to low, poor	735	140		626	249		589	286		666	209
Borrmann type			0.220			0.000			0.029			0.000
I and II	381	61		353	89		324	118		391	51
III and IV	662	132		551	243		534	260		578	216
Size			0.305			0.000			0.000			0.000
< 5	589	101		555	135		528	162		590	100
≥ 5	454	92		349	197		330	216		379	167
Survival status			0.000			0.000			0.000			0.000
Alive	736	106		686	156		646	196		728	114
Dead	307	87		218	176		212	182		241	153

AFP: Alpha foetoprotein; CEA: Carcinoembryonic antigen.