Performance of nutritional and inflammatory markers in patients with pancreatic cancer

doi:10.5306/wjco.v15.i8.1021

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Oncol. Aug 24, 2024; 15(8): 1021-1032
Published online Aug 24, 2024. doi: 10.5306/wjco.v15.i8.1021

Table 5 Univariable and multivariable Cox regression analysis of overall survival

Characteristics	Univariable analysis		Multivariable analysis
Characteristics	HR	P value	HR	P value
Demographics
Age (years)	1.027 (1.009-1.046)	0.004^b	1.021 (1.000-1.041)	0.046^a
Gender (male/female)	1.148 (0.845-1.561)	0.377
BMI (kg/m²)	0.932 (0.886-0.980)	0.006^b
Smoke (yes/no)	1.280 (0.941-1.740)	0.115
Hypertension (yes/no)	0.843 (0.621-1.145)	0.275
Type 2 diabetes (yes/no)	0.996 (0.718-1.382)	0.982
Tumor biomarkers
sCA19-9 (U/mL) ≥ 37 vs < 37	1.283 (0.880-1.871)	0.195
sCA125 (U/mL) ≥ 35 vs < 35	1.413 (0.974-2.049)	0.068
Tumor features
Location (body/tail vs head/neck)	0.663 (0.482-0.911)	0.011^a
Degree of differentiation		0.003^b		0.012^a
Poor	2.804 (1.433-5.487)	0.003^e	2.369 (1.200-4.675)	0.013^d
Moderate	1.899 (0.985-3.661)	0.056	1.592 (0.822-3.084)	0.168
Well	Reference
Tumor stage (TNM)		< 0.001^c		0.001^c
Early stage (Ⅰ)	0.405 (0.260-0.632)	< 0.001^f	0.448 (0.281-0.715)	< 0.001^f
Middle stage (Ⅱ/Ⅲ)	0.725 (0.474-1.109)	0.138	0.737 (0.473-1.149)	0.178
Advanced stage (Ⅳ)	Reference
Inflammatory-nutritional markers
AGR	0.415 (0.212-0.813)	0.010^a
Ln (PNI)	0.025 (0.008-0.079)	< 0.001^c	0.048 (0.015-0.155)	< 0.001^c
Ln (SII)	1.432 (1.122-1.829)	0.004^b
Ln (NLR)	1.788 (1.344-2.378)	< 0.001^c
Ln (PLR)	1.839 (1.277-2.647)	0.001^b
Ln (NRI)	0.018 (0.004-0.078)	< 0.001^c
Ln (GNRI)	0.018 (0.004-0.079)	< 0.001^c

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

^dP < 0.05 vs reference.

^eP < 0.01 vs reference.

^fP < 0.001 vs reference.

AGR: Albumin to globulin ratio; BMI: Body mass index; GNRI: Geriatric nutritional risk index; HR: Hazard ratio; NLR: Neutrophil to lymphocyte ratio; NRI: Nutritional risk index; PLR: Platelet to lymphocyte ratio; PNI: Prognostic nutrition index; sCA19-9: Serum carbohydrate antigen 19-9; sCA125: Serum carbohydrate antigen 125; SII: Systemic immune-inflammation index. Ln (PNI), Ln (SII), Ln (NLR), Ln (PLR), Ln (NRI) and Ln (GNRI) refers to the natural log-transformed value of the inflammatory-nutritional markers respectively.

Citation: Lu JN, Zhou LS, Zhang S, Li JX, Xu CJ. Performance of nutritional and inflammatory markers in patients with pancreatic cancer. World J Clin Oncol 2024; 15(8): 1021-1032
URL: https://www.wjgnet.com/2218-4333/full/v15/i8/1021.htm
DOI: https://dx.doi.org/10.5306/wjco.v15.i8.1021