Performance of nutritional and inflammatory markers in patients with pancreatic cancer

Table 4 Univariable and multivariable Cox regression analysis of recurrence-free survival

Characteristics	Univariable analysis		Multivariable analysis
	HR	P value	HR	P value
Demographics
Age (years)	1.001 (0.985-1.018)	0.862
Gender (male/female)	1.071 (0.804-1.425)	0.641
BMI (kg/m2)	0.973 (0.929-1.018)	0.232
Smoke (yes/no)	1.007 (0.748-1.356)	0.963
Hypertension (yes/no)	0.829 (0.623-1.104)	0.199
Type 2 diabetes (yes/no)	0.923 (0.678-1.257)	0.610
Tumor biomarkers
sCA19-9 (U/mL) ≥ 37 vs < 37	1.164 (0.821-1.652)	0.394
sCA125 (U/mL) ≥ 35 vs < 35	1.277 (0.892-1.828)	0.181
Tumor features
Location (body/tail vs head/neck)	0.854 (0.636-1.146)	0.293
Degree of differentiation		0.014a
Poor	2.455 (1.321-4.565)	0.005e
Moderate	1.908 (1.048-3.474)	0.035d
Well	Reference
Tumor stage (TNM)		< 0.001c		< 0.001c
Early stage (Ⅰ)	0.397 (0.253-0.621)	< 0.001f	0.384 (0.241-0.612)	< 0.001f
Middle stage (Ⅱ/Ⅲ)	0.640 (0.413-0.993)	0.046d	0.613 (0.388-0.967)	0.035d
Advanced stage (Ⅳ)	Reference
Inflammatory-nutritional markers
AGR	0.887 (0.488-1.611)	0.694
Ln (PNI)	0.203 (0.062-0.665)	0.008b	0.256 (0.076-0.863)	0.028a
Ln (SII)	1.276 (1.019-1.597)	0.034a
Ln (NLR)	1.439 (1.102-1.880)	0.008b
Ln (PLR)	1.443 (1.033-2.016)	0.031a
Ln (NRI)	0.299 (0.066-1.352)	0.117
Ln (GNRI)	0.299 (0.066-1.353)	0.117

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

^dP < 0.05 vs reference.

^eP < 0.01 vs reference.

^fP < 0.001 vs reference.

AGR: Albumin to globulin ratio; BMI: Body mass index; GNRI: Geriatric nutritional risk index; HR: Hazard ratio; NLR: Neutrophil to lymphocyte ratio; NRI: Nutritional risk index; PLR: Platelet to lymphocyte ratio; PNI: Prognostic nutrition index; sCA19-9: Serum carbohydrate antigen 19-9; sCA125: Serum carbohydrate antigen 125; SII: Systemic immune-inflammation index. Ln (PNI), Ln (SII), Ln (NLR), Ln (PLR), Ln (NRI) and Ln (GNRI) refers to the natural log-transformed value of the inflammatory-nutritional markers respectively.