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©The Author(s) 2024.
World J Clin Oncol. Jul 24, 2024; 15(7): 848-858
Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.848
Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.848
Table 2 Clinical outcomes of poly (ADP-ribose) polymerase inhibitor therapy in BRCA gene-positive breast cancer and homologous recombination deficiency-positive ovarian cancer patients
Cancer type | Patient | Stage | Response change to PARPi | Duration of PARPi | PARPi status at end of study |
BRCA+ breast cancer, 5/15 (33.3%) | 1 | II | CR–DF | 13 months+ | On Rx |
21 | II | PR–PR | 40 days | Stopped | |
3 | III | CR–DF | 17 months+ | On Rx | |
4 | IV | PR–PR | 5 months | Stopped | |
52 | IV | PR | 7 months | Stopped | |
HRD+ ovarian cancer, 4/6 (66.6%) | 1 | III | PR–DF | 15 months+ | On Rx |
2 | IV | CR–DF | 13 months+ | On Rx | |
3 | IV | SD–PRF | 20 months+ | On Rx | |
4 | IV | CR–DF | 25 months+ | On Rx |
- Citation: Syed N, Chintakuntlawar AV, Vilasini D, Al Salami AM, Al Hasan R, Afrooz I, Uttam Chandani K, Chandani AU, Chehal A. Low testing rates and high BRCA prevalence: Poly (ADP-ribose) polymerase inhibitor use in Middle East BRCA/homologous recombination deficiency-positive cancer patients. World J Clin Oncol 2024; 15(7): 848-858
- URL: https://www.wjgnet.com/2218-4333/full/v15/i7/848.htm
- DOI: https://dx.doi.org/10.5306/wjco.v15.i7.848