Low testing rates and high BRCA prevalence: Poly (ADP-ribose) polymerase inhibitor use in Middle East BRCA/homologous recombination deficiency-positive cancer patients

doi:10.5306/wjco.v15.i7.848

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Jul 24, 2024 (publication date) through Jul 16, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jul 24, 2024; 15(7): 848-858
Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.848

Table 2 Clinical outcomes of poly (ADP-ribose) polymerase inhibitor therapy in BRCA gene-positive breast cancer and homologous recombination deficiency-positive ovarian cancer patients

Cancer type	Patient	Stage	Response change to PARPi	Duration of PARPi	PARPi status at end of study
BRCA+ breast cancer, 5/15 (33.3%)	1	II	CR–DF	13 months+	On Rx
	2¹	II	PR–PR	40 days	Stopped
	3	III	CR–DF	17 months+	On Rx
	4	IV	PR–PR	5 months	Stopped
	5²	IV	PR	7 months	Stopped
HRD+ ovarian cancer, 4/6 (66.6%)	1	III	PR–DF	15 months+	On Rx
	2	IV	CR–DF	13 months+	On Rx
	3	IV	SD–PRF	20 months+	On Rx
	4	IV	CR–DF	25 months+	On Rx

¹Received three cycles of neoadjuvant chemotherapy and then lost to follow-up and received poly (ADP-ribose) polymerase inhibitor in the advanced stage.

²Received olaparib as first line. + indicates the status of still receiving poly (ADP-ribose) polymerase inhibitor at the time of data collection/study end.

CR: Complete remission, DF: Disease-free; HRD: Homologous recombination deficiency; PR: Partial response; PRF: Progression-free; SD: Stable disease.

Citation: Syed N, Chintakuntlawar AV, Vilasini D, Al Salami AM, Al Hasan R, Afrooz I, Uttam Chandani K, Chandani AU, Chehal A. Low testing rates and high BRCA prevalence: Poly (ADP-ribose) polymerase inhibitor use in Middle East BRCA/homologous recombination deficiency-positive cancer patients. World J Clin Oncol 2024; 15(7): 848-858
URL: https://www.wjgnet.com/2218-4333/full/v15/i7/848.htm
DOI: https://dx.doi.org/10.5306/wjco.v15.i7.848