Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

Table 2 Crude analysis of factors associated with all-cause mortality and hepatosplenic T-cell lymphoma mortality among patients between 2000 and 2017

Characteristics	Overall mortality crude proportional hazard ratio (95% confidence interval)	HSTCL crude proportional hazard ratio (95% confidence interval)
Gender
Female	1 (reference)	1 (reference)
Male	0.96 (0.65-1.39)	0.99 (0.65-1.52)
Age at diagnosis, yr
0-39	1 (reference)	1 (reference)
40-59	0.80 (0.53-1.22)	0.69 (0.44-1.11)
60-79	0.95 (0.59-1.54)	0.85 (0.50-1.45)
80+	1.60 (0.68-3.77)	1.44 (0.57-3.65)
Race
Non-Hispanic white	1 (reference)	1 (reference)
Non-Hispanic black	1.97 (1.27-3.07)b	2.34 (1.47-3.72)b
Hispanic	1.44 (0.71-2.89)	1.41 (0.64-3.13)
Other	1.65 (0.96-2.86)	1.62 (0.86-3.04)
Tumor stage
Localized	1 (reference)	1 (reference)
Regional	1.28 (0.57-2.86)	1.63 (0.62-4.30)
Distant	1.54 (0.97-2.43)	2.23 (1.24-4.02)b
Living area
Counties in metropolitan areas of 1 million persons	1 (reference)	1 (reference)
Counties in metropolitan areas of 250000 to 1 million persons	0.73 (0.46-1.16)	0.69 (0.41-1.17)
Counties in metropolitan areas of 250000 persons	1.19 (0.63-2.24)	1.02 (0.49-2.12)
Nonmetropolitan counties	1.43 (0.76-2.70)	1.22 (0.59-2.56)
Income per year
$ < $55000	1 (reference)	1 (reference)
$55000-64999	1.26 (0.65-2.45)	1.39 (0.65-2.99)
$65000-74999	1.18 (0.63-2.20)	1.25 (0.59-2.61)
$75000+	0.82 (0.45-1.49)	1.02 (0.51-2.03)
Marital status
Married	1 (reference)	1 (reference)
Single/unknown	1.12 (0.76-1.64)	1.32 (0.86-2.04)
Divorced/separated	1.49 (0.8-2.85)	1.77 (0.88-3.56)
Widowed	1.98 (0.89-4.38)	1.82 (0.72-4.65)
Radiation
No	1 (reference)	1 (reference)
Yes	0.77 (0.37-1.58)	0.81 (0.38-1.75)
Surgery
No	1 (reference)	1 (reference)
Yes	0.76 (0.53-1.09)	0.72 (0.48-1.09)
B symptoms
No	1 (reference)	1 (reference)
Yes	1.23 (0.85-1.80)	1.14 (0.75-1.75)

^bP < 0.01.

HSTCL: Hepatosplenic T-cell lymphoma.