Gallbladder cancer: Progress in the Indian subcontinent

Table 3 Clinico pathological studies

Serial No.	Sample size	Findings	Ref.
1	GBC (50)	Her2 neu, p53, p16, survivin, COX-2, and EZH-2 expression associated with GBC	Gupta et al[115]
2	GBC (200), Dysplasia (32), CC (100)	HER-2/neu overexpression seen in patients with GBC	Jain et al[116]
3	GBC (128)	HER 2 and Ki-67 can be used as a prognostic biomarker for gallbladder carcinoma	Halder et al[117]
4	-	Combination of ALU247 and cfDNA provides good sensitivity, specificity in diagnosis of GBC	Kumari et al[118]
5	-	Proposed a scoring system for XGC	Rajaguru et al[119]
6	GBC (34)	Quantitative analysis of cfDNA may aid in early diagnosis	Kumari et al[120]
7	GBC (39), cholelithiasis (30), and control (25)	Overexpression of survivin is associated with poor prognosis	Nigam et al[121]
8	(GSD, n =30; GBC, n = 39) healthy control (n = 25)	Expression of survivin in peripheral blood could be useful both in the diagnosis and prognosis of GBC	Nigam et al[122]
9	GBC (80)	P53 expression is positively correlated with increasing tumor grade, whereas beta-catenin nuclear expression is associated with tumor grade and depth of invasion	Ghosh et al[123]
10	9 case of Squamous cell carcinoma	Ultrasound-guided fine-needle aspiration is a useful minimally invasive investigation in the preoperative diagnosis of squamous cell carcinoma of the gallbladder	Gupta and Gupta[124]
11	GBC (55), vontrols (8)	Assay of CA242, CA19-9, CA15-3, and CA125 can be used as marker of carcinoma of the gallbladder	Shukla et al[125]
12	GBC (40)	Intraoperative bile cytology can be used for diagnosis of in situ and early invasive GBC	Arora et al[126]

GBC: Gallbladder cancer; CC: Chronic cholecystitis.