Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance

Figure 1 Different types of tumor microvessels. A: Normal microvessels. Scale bar = 10 μm; B: Dilated capillaries (DCs). Scale bar = 100 μm; C: Atypical DCs with tumor emboli (orange arrows) and cluster of differentiation 34 (CD34)-positive cells (red arrow) in their lumen, Scale bar = 100 μm; D: Lymphatic capillary with the chaotic arrangement of the endothelial cells. Scale bar = 10 μm; E: DCs with weak expression of CD34 (orange arrows). Scale bar = 10 μm; F: Contact-type DCs (orange arrow). Scale bar = 100 μm; G: Structures with partial endothelial lining (type 1, orange arrows), structures without endothelial lining (blue arrows) and vessels with complexes of tumor cells in their lumen (red arrows). Scale bar = 100 μm; H: Structures with partial endothelial lining (type 2). Scale bar = 10 μm; I: Capillaries in the tumor solid component (type 1). Scale bar = 100 μm; J: Capillaries in the tumor solid component (type 2). Scale bar = 10 μm; K: Lymphatic capillary in lymphoid and polymorphic cell infiltrates. Scale bar = 100 μm; L: Lymphatic capillary in lymphoid and polymorphic cell infiltrates. Scale bar = 10 μm scale; A-C, E-K: Staining with antibodies against CD34; D and L: Staining with antibodies against PDPN.