Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance

doi:10.5306/wjco.v15.i5.614

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World Journal of Clinical Oncology

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2218-4333

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Retrospective Cohort Study

World J Clin Oncol. May 24, 2024; 15(5): 614-634
Published online May 24, 2024. doi: 10.5306/wjco.v15.i5.614

Table 4 Univariate and multivariate analyses for the predictors of disease recurrence in patients with lung squamous cell carcinoma

Characteristic	Univariate analysis, OR (95%CI)	P value	Multivariate analysis, OR (95%CI)	P value
Age
< 60	1	-
60-69	1.87 (0.97-3.58)	0.06
≥ 70	2.45 (0.89-6.72)	0.082
Tumor location
Peripheral	1	-	1	-
Central	1.86 (0.99-3.47)	0.052^a	1.04	0.92
Histology
KSCC	1	-
NKSCC	1.79 (0.94-3.38)	0.075
Tumor grade
G1	1	-	1	-
G2	1.51 (0.76-2.95)	0.232	1.36 (0.59-3.01)	0.466
G3	3.44 (1.39-8.48)	0.007^a	4.24 (1.37-13.14)	0.001^a
T stage
T1a	1	-
T1b	7.00 (1.04-46.95)	0.045^a
T2a	4.26 (0.83-21.74)	0.082
T2b	5.00 (0.79-31.62)	0.087
T3	3.38 (0.65-17.69)	0.149
N stage
N0	1	-	1	-
N1	2.00 (0.97-4.11)	0.059	1.89 (0.81-4.39)	0.137
N2	3.22 (1.37-7.57)	0.007^a	3.43 (1.26-9.34)	0.016^a
Stage
I	1	-	1	-
II	2.17 (0.89-5.27)	0.088	1.87 (0.45-7.69)	0.385
III	3.13 (1.29-7.60)	0.012^a	3.44 (0.50-23.49)	0.207
Adjuvant therapy
Radiation therapy	1	-	1	-
Chemo- and radiotherapy	1.41 (0.50-3.97)	0.513	0.57 (0.16-1.98)	0.376
Chemotherapy	3.02	0.008	2.07 (0.78-5.53)	0.146
DCs with weak expression of CD34
Absence	1	-	1	-
Presence	4.26 (2.25-8.05)	0.0000^a	1.18 (0.43-3.23)	0.749
Contact-type DCs
Absence	1	-
Presence	0.97 (0.54-1.75)	0.934
The capillaries in the tumor solid component
Absence	1	-	1	-
Presence	2.32 (1.24-4.35)	0.008^a	1.20 (0.56-2.59)	0.638
LFFCT in the tumor stroma
Absence	1	-	1	-
Presence	6.24 (2.85-13.67)	0.0000^a	7.34 (3.03-17.76)	0.0000^a
Fragmentation of the tumor solid component
Absence	1	-	1	-
Presence	3.03 (1.58-5.82)	0.0009^a	5.23 (2.27-12.07)	0.0001^a
Retraction clefts
Absence	1	-
Presence	0.71 (0.38-1.29)	0.262
Tumor spread through the AASs
Presence	1	-	1	-
Absence	2.06 (1.13-3.76)	0.019^a	3.37 (1.22-5.66)	0.0083^a

^aP < 0.05, the differences between groups are statistically significant.

AASs: Alveolar air spaces; DCs: Dilated capillaries; KSCC: Keratinizing squamous cell carcinoma; LFFCT: Loose, fine fibrous connective tissue in the tumor stroma; NKSCC: Nonkeratinizing squamous cell carcinoma; OR: Odds ratio; CD34: Cluster of differentiation 34.

Citation: Senchukova MA, Kalinin EA, Volchenko NN. Different types of tumor microvessels in stage I-IIIA squamous cell lung cancer and their clinical significance. World J Clin Oncol 2024; 15(5): 614-634
URL: https://www.wjgnet.com/2218-4333/full/v15/i5/614.htm
DOI: https://dx.doi.org/10.5306/wjco.v15.i5.614