Immune pathway through endometriosis to ovarian cancer

Figure 5 Illustration of anti-CSF-1R-based immunotherapy. The colony-stimulating factor-1 receptor (CSF-1R) is a receptor that exists in several human cells during homeostasis, but is overexpressed in tumor-associated macrophages in ovarian cancer. The use of a monoclonal antibody directed at blocking CSF-1R in cancer patients, aims to manipulate the activity of TAMs, reducing tumor-associated macrophages in patients, as well as an increase in the levels of TCD8/CD4 cells in animal models. Anti-CSF-1R: Colony-Stimulating Factor 1 receptor Antibody CSF-1: Colony-Stimulating Factor 1; CSF-1R: Colony-Stimulating Factor 1 receptor; M2 TAM Φ: Tumor-associated macrophages M2; OC cell: Ovarian Cancer cells; TAM Φ: Tumor-associated macrophages.