PD-1 antibody in combination with chemotherapy for the treatment of SMARCA4-deficient advanced undifferentiated carcinoma of the duodenum: Two case reports

doi:10.5306/wjco.v15.i3.456

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Mar 24, 2024 (publication date) through Jul 17, 2024

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World Journal of Clinical Oncology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Mar 24, 2024; 15(3): 456-463
Published online Mar 24, 2024. doi: 10.5306/wjco.v15.i3.456

Table 1 Genomic profile of somatic alterations for the patients

	Gene	Transcript description	Mutant allele frequency
Case 1	TP53	NM_000546.5:c.742C>T(p.Arg 248Trp)	20.9%
	CTNNB1	NM_001098209.1:c.134C>T(p.Ser45Phe)	23.4%
Case 2	TP53	NM_000546.5: c.1024C>T(p.R342)	23.2%
	NCOR1	NM_006311.3 :c.5689T>G (p.S1897A)	18.7%
	MYH9	NM_002473.4 : c.1560C[6>7] (p.I524Hfs*44)	15.9%
	ERBB3	NM_001982.3 : c.850G>C (p.G284R)	15.0%
	RAD52	NM_134424.2 : c.779G>A (p.R260Q)	14.8%
	CTNNB1	NM_001904.3 :c.133T>C (p.S45P)	14.2%

Citation: Shi YN, Zhang XR, Ma WY, Lian J, Liu YF, Li YF, Yang WH. PD-1 antibody in combination with chemotherapy for the treatment of SMARCA4-deficient advanced undifferentiated carcinoma of the duodenum: Two case reports. World J Clin Oncol 2024; 15(3): 456-463
URL: https://www.wjgnet.com/2218-4333/full/v15/i3/456.htm
DOI: https://dx.doi.org/10.5306/wjco.v15.i3.456