Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

Figure 3 Interplay between antitumoral and antiviral activities induced by interferon-gamma in the pulmonary context. A: Heat map of interferon-gamma (IFN-γ) signaling components and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, angiotensin-converting enzyme 2 (ACE2), in lung adenocarcinoma (LUAD). IFNG, IFNGR2, IFNGR1, JAK1, JAK2, and DNAJA3 expression in human LUAD tumors and normal tissue. Selamat Lung datasets; B: Proposed model: There is a functional IFN-γ signaling pathway for controlling cell proliferation and viral infections in normal conditions. In LUAD, there is an increase in the ACE2 expression, facilitating the SARS-CoV-2 infection. Moreover, the expression of IFN-γ signaling components is reduced, decreasing the antiproliferation and antiviral defenses. IFN-γ: Interferon-gamma; GAS: Gamma-activated sequence; ISGs: Interferon-stimulated genes.