Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

Figure 1 Canonical signaling pathway of interferon-gamma. The heterotetrameric receptor complex for interferon-gamma (IFN-γ) comprises IFNGR1 and IFNGR2. JAK1 and JAK2 proteins are associated with intracellular domains of IFNGR1 and IFNGR2, respectively. The binding of IFN-γ to its receptor complex promotes the transphosphorylation of JAK1/2, the phosphorylation of IFNGR1, and the recruitment of STAT1, followed by the STAT1 phosphorylation by JAK proteins. Phosphorylated STAT1 translocates into the nucleus to modulate the transcription of genes containing gamma-activated sequence motifs in their promoter regions. IFN-γ: Interferon-gamma; GAS: Gamma-activated sequence; ISGs: Interferon-stiumlated genes.