Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer

Figure 3 The expression of synaptotagmin binding cytoplasmic RNA interacting protein mRNA in colorectal cancer is higher than in non-tumorous tissue based on high-throughput array and sequence data. A: 22 datasets were obtained and integrated. The expression distribution of each dataset was close to Gaussian distribution; B: The expression of synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP) in each dataset was calculated, and the high expression tendency of SYNCRIP in colorectal cancer (CRC) with significant statistical value in 14 datasets. Blue boxes were the CRC samples and the red boxes were the normal samples. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001; ^dP < 0.0001; C: According to the standard mean deviation (SMD) model, SYNCRIP was exactly up-regulated in CRC compared to non-cancerous tissue with SMD = 1.20 (95%CI: 1.12-1.27, I² = 90.3%). The blue diamond represented the effect size of SYNCRIP in each dataset, and the red line was the error bar; D: The summary receiver operating characteristic curve and area under the curve (AUC) were calculated. Blue points were the datasets and the red curve were the boundary of AUC. SYNCRIP: Synaptotagmin binding cytoplasmic RNA interacting protein.