Cervical myeloid sarcoma as an initial clinical manifestation: Four case reports

Table 1 Information on patients with cervical myeloid sarcoma reported in the current study and in the literature (2013-2023)

Ref.	Published year	Age	Tumor size	Symptoms	With/without AML at diagnosis or previous	Initial treatment	Progression and subsequent treatment	Follow-up (months)	Outcome
Case 1	-	49	8.8	Vaginal bleeding	No	DA chemotherapy + surgery + chemotherapy	Multi-site recurrence	22	Death
Case 2	-	54	6.4	Vaginal bleeding	Yes	Withdrawing treatment	-	1.5	Death
Case 3	-	46	3	Vaginal bleeding	No	DA chemotherapy + surgery + DA chemotherapy	-	36	Survival
Case 4	-	48	7.2	Vaginal bleeding	No	Chemotherapy + surgery + MA chemotherapy	Lung metastasis	9	Death
Jiang et al[4]	2015	66	1.2	Vaginal bleeding	No	Surgery + IA chemotherapy + radiotherapy	-	6	Survival
Wu and He[5]	2014	25	8.4	Vaginal bleeding	No	IA chemotherapy	-	3	Survival
Liu et al[6]	2013	27	8.5	Contact bleeding	No	Abandoning treatment after surgery	-	15	Survival
Wang et al[7]	2014	43	6	Contact bleeding	No	DA chemotherapy + intrathecal injection	-	7	Survival
Peng et al[8]	2019	39	11	Vaginal bleeding	No	Surgery + chemotherapy	-	2	Survival
Zuo et al[9]	2016	42	4	Vaginal bleeding	No	Surgery + DA chemotherapy	Transformation into AML during chemotherapy	12	Death
Zuo et al[9]	2016	51	4.5	No	No	E-CHOP chemotherapy + CHEP chemotherapy + surgery + DA chemotherapy	Gingival metastases at 55 months, with radiation and chemotherapy + bone marrow transplant	91	Survival
Zhang and Cai[10]	2017	23	6.9	Vaginal bleeding	Diagnosed with AML-M2 5 years ago	MA chemotherapy	-	1	Survival
Jiang et al[11]	2017	28	-	Vaginal bleeding	No	Chemotherapy	Progressed into AML-M2a within 5 months	20	Death
Jiang et al[12]	2017	49	-	Vaginal bleeding	No	Withdrawing treatment	-	5	Death
Jiang et al[12]	2017	43	-	Vaginal bleeding	No	Radiotherapy + chemotherapy	-	7	Death
Feng et al[13]	2017	57	2.5	Contact bleeding	No	Withdrawing treatment	-	6	Survival
Yu and Ye[14]	2013	28	4.5	Vaginal bleeding	No	IA chemotherapy	-	18	Death
Gill et al[15]	2013	36	2	Vaginal bleeding	No	Chemotherapy	-	16	Survival
Abu Saadeh et al[16]	2015	40	5	No	Diagnosed with AML 11 years ago	Surgery + chemotherapy + radiotherapy	-	21	Survival
Mishra et al[17]	2018	36	2	Increased menstrual flow	Yes	Chemotherapy	Multiple lymph node infiltrations detected on the 31st day of chemotherapy	1.5	Death
Ucar et al[18]	2014	23	-	Vaginal bleeding	Diagnosed with AML 3 years ago	Chemotherapy	-	2	Survival
Gui et al[19]	2019	46	6	Contact bleeding	No	Surgery + chemotherapy	Multi-site recurrence, without AML	21	Death
Gui et al[19]	2019	39	6.9	Vaginal bleeding	No	Surgery + chemotherapy	Progressed into AML within 5 months	26	Death
Shatilova et al[20]	2021	49	7.6	Vaginal bleeding	Uncertain	DA chemotherapy	Bone marrow transplantation	4	Survival
Choi et al[21]	2022	49	3.4	Vaginal bleeding	Diagnosed with MDS, but not AML	Surgery	-	-	-

AML: Acute myeloid leukemia; IA: Idarubicin and Ara-C; DA: Daunorubicin and Ara-C; E-CHOP: Etoposide, chlorambucil, doxorubicin, prednisone and vincristine; CHEP: Cyclophosphamide, hydroxydaunorubicin, vincristine and prednisone; MA: Mitoxantrone and Ara-C; MDS: Myelodysplastic syndrome.