Copyright
©The Author(s) 2024.
World J Clin Oncol. Jan 24, 2024; 15(1): 9-22
Published online Jan 24, 2024. doi: 10.5306/wjco.v15.i1.9
Published online Jan 24, 2024. doi: 10.5306/wjco.v15.i1.9
Figure 2 Molecular structure diagram of six transmembrane epithelial antigens of the prostate 1-4.
The six transmembrane epithelial antigens of the prostate (STEAP) family is composed of a group of cell surface transmembrane proteins with six potential transmembrane domains, one intracellular amino terminus, and a carboxyl terminus that exert physiological functions by acting as oxidoreductases. STEAP1-4 consist of 339, 490, 488, and 459 amino acid residues, respectively. Except STEAP1, the N-terminus of the STEAP2-4 proteins contains the F420H2:NADP+ oxidoreductase binding protein domain. TM: Transmembrane domain; STEAP: Six transmembrane epithelial antigen of the prostate.
- Citation: Fang ZX, Chen WJ, Wu Z, Hou YY, Lan YZ, Wu HT, Liu J. Inflammatory response in gastrointestinal cancers: Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications. World J Clin Oncol 2024; 15(1): 9-22
- URL: https://www.wjgnet.com/2218-4333/full/v15/i1/9.htm
- DOI: https://dx.doi.org/10.5306/wjco.v15.i1.9