Inflammatory response in gastrointestinal cancers: Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications

Figure 1 Schematic representation of protein structure of six transmembrane epithelial antigens of the prostate. Six transmembrane epithelial antigens of the prostate (STEAPs) are similar in structure, with six transmembrane domains, an intracellular C-terminus, and an intracellular N-terminus containing the intracellular heme group, while STEAP1 Lacks FNO-like domain to perform intrinsic metal reductase activity. STEAP2-4 are involved in cell proliferation, tumor progression, and intercellular communication through their metalloreductase activity. FNO: F420H2:NADP+ oxidoreductase.