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Copyright ©The Author(s) 2023.
World J Clin Oncol. Sep 24, 2023; 14(9): 324-334
Published online Sep 24, 2023. doi: 10.5306/wjco.v14.i9.324
Table 1 Copper-related compounds and their antitumor mechanism
Compounds
Mechanism
Ref.
ElesclomolTransferring copper ions to mitochondria and increasing ROS levelNagai et al[7]
Flavonoid drugsInterfering with copper ion redox and inducing mitochondrial apoptosisLiu et al[8]
(Cu(DDC)2)Inhibiting proteasome and leading to ER stress activationChen et al[9]
Copper ion chelating agentInhibiting endothelial cell proliferation and angiogenesisZhou et al[15]
Copper ion transporter inhibitorInhibit endothelial cell proliferation and angiogenesisYee et al[13], Karginova et al[14]
NPs(Cu-CysNPs)Reacting with glutathione to increase ROS levelMa et al[18]
Cu-TSCInducing ROS accumulationSîrbu et al[19]
Cu-NSAID compoundInducing ROS accumulation, DNA damage and COX-2 activity inhibitionBoodram et al[20]
Copper complexes containing polypyridine ligandsIncreasing ROS level and inducing ER stressKaur et al[21]