Role of prophylactic central neck lymph node dissection for papillary thyroid carcinoma in the era of de-escalation

Table 3 Results of routine prophylactic central neck lymph node dissection in papillary thyroid carcinoma

Ref.	Patients (Nu)	Trial	Findings
Barczyński et al[34], 2013	640	Single center retrospective study	Bilateral pCND increases 10-yr disease-specific survival and locoregional control, No increased risk of permanent morbidity
Lee et al[62], 2007	103	Single center retrospective study	Increased transient hypocalcemia in bilateral than ipsilateral pCND
Chisholm et al[63], 2009	1132	Meta-analysis	No increased permanent morbidity
Zhu et al[64], 2013	2298	Meta-analysis	No more complications
Wang et al[69], 2023	2080	Meta-analysis	Reduced local recurrence; Higher risk of permanent hypocalcemia and transient hypopara-thyroidism; No significant differences in transient hypocalcemia, permanent hypopara-thyroidism, both temporary and permanent vocal cord paralysis, and recurrent laryngeal nerve injury

pCND: Prophylactic central neck lymph node dissection.