Computational exploration of the significance of COPS6 in cancer: Functional and clinical relevance across tumor types

Figure 1 Differential expression analysis of COP9 signalosome subunit 6 in pan-cancer. A: Overview of the pan-cancer analysis workflow; B: Differential expression analysis of COP9 signalosome subunit 6 (COPS6) in the The Cancer Genome Atlas (TCGA) database using the Wilcoxon test in R software; C: Differential expression analysis of COPS6 in matched TCGA normal and Genotype-Tissue Expression data using the GEPIA2 website with specific cutoff criteria. ^bP ＜ 0.01；^cP ＜ 0.001. CHOL: Cholangiocarcinoma; DFI: Disease-free interval; DLBC: Diffuse large B-cell; DSS: Disease-specific survival; GO: Gene ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; LAML: Acute myeloid leukemia; MIS: Microsatellite instability; OS: Overall survival; PAAD: Pancreatic adenocarcinoma; PFI: Progression-free interval; SKCM: Skin cutaneous melanoma; THYM: Thymoma; TMB: Tumor mutational burden.