Autoimmune diabetes from pembrolizumab: A case report and review of literature

Table 2 Diabetes characteristics

Ref.	Presentation	HbA1C	C-peptide	Auto Ab	Outcome
de Filette et al[9]	DKA		0.02 nmol/L	GADA	Not known
de Filette et al[9]	71% DKA	7.6	Low in 84%	51% GADA 18% IA213% ICA26% Anti-Insulin	Not known
Clotman et al[10]	DKA	7.1	Low	GADA, ICA	Stayed on insulin
Clotman et al[10]	70% DKA	7.5	Low in 93%	56% GADA
Farina et al[11]	69% DKA	7.76	0.1	50% GADA+	97% remained on Insulin therapy
Kyriacou et al[12]	DKA	7	Low	GADA+	Stayed on insulin
Banatwalla et al[13]	DKA	8.2	0.09	All neg	Stayed on insulin
Hernandez et al[14]	DKA	6.9			Stayed on insulin
Bansal et al[15]	HHS	8.3	Normal	GADA +	Stayed on insulin
Kedzior et al[16]	DKA	8.3	Undetected	GADA+
Cunha et al[17]	DKA	5.6	Undetected	GADA+	Stayed on insulin
Kähler et al[18]	DKA	9.7, 6.5, 7.5, No data for other 2	Low in 1	GADA+ in 2
Tohi et al[19]	DKA	6.7	Undetected	GADA negative	Stayed on insulin
Edahiro et al[20]	DKA	8.4	Low	GADA negative	Stayed on insuline
Magis et al[21]	DKA	6.8	< 0.003	GADA negative,IA-2 Positive	Stayed on insulin
Samoa et al[22]	DKA	8.9, Intial was 6.0	Low	GADA negative,IA-2 PositiveIA Positive	Stayed on insulin
Li et al[23]	DKA	8	Low	All ab negative	Stayed on insuline
Boyle et al[24]	DKA	7.4	Low	All ab negative	Stayed on insulin
Boyle et al[24]	DKA		Low	All ab negative
Sankar et al[25]	DKA	6.8		All ab negative	Stayed on insulin
Hakami et al[26]	DKA	8.3	< 0.001	All ab negative	Stayed on insulin
Chaudry et al[27]	DKA			GADA +	Stayed on insulin
Kotwal et al[28]	8 DKA,1 HHS,1 Ketosis,1 Hyperglycemia	9.7	5/6 Low	4/7 GADA+, 1/7 IAA+, 1/7 IA2A+	Stayed on insulin
Zand et al[29]	DKA	8.9		All ab negative	Stayed on insulin
Maamari et al[30]	DKA	6.4	Low	GADA+	Stayed on insulin
Alrifai et al[31]	DKA	9.2	Low	GADA+	Stayed on insulin
Hong et al[32]	DKA	10.4	Low	All ab negative	Stayed on insulin
Hong et al[32]	DKA	11.4	Low	All ab negative	Stayed on insulin
Hong et al[32]	DKA	5.8	Low	All ab negative	Stayed on insulin
Skorpen et al[33]	DKA	8.4	Undetected	All ab negative	Stayed on insulin
Martin-Liberal et al[34]	DKA			GADA+	Stayed on insulin
Gaudy et al[35]	DKA	6.85	Undetected	All ab negative	Stayed on insulin
Aleksova et al[36]	DKA		Low	All ab negative	Stayed on insulin
M A et al[37]	DKA	10.7		All ab negative	Stayed on insulin
Hansen et al[38]	Simple T1DM	7.1	Low	GADA+	Dced insulin
Alhusseini et al[39]	DKA	8.5	Undectable	GADA+, ICA+	Stayed on insulin
F A et al[40]	DKA	8	Undectable	GADA+, IA+	Stayed on insulin
Tay et al[41]	DKA	9.3	Undectable	All ab Negative	Stayed on insulin
Chae et al[42]	DKA	5.8	Low	GADA+, ICA+	Stayed on insulin
Smith-Cohn et al[43]	DKA	8.7		GADA+	Stayed on insulin
C M et al[44]	DKA	7.4	Undetectable	All ab Negative
Abayev et al[45]	DKA	11.8	Normal	All ab Negative	Stayed on insulin
Ioana et al[46]	DKA	8.3	Undetectable	All ab Negative
Kalkan et al[47]	DKA		Low	All ab Negative
Reslan et al[48]	DKA	7.5			Stayed on insulin
Fernandez et al[49]	DKA	5.5	Low	GADA+
Sfeir et al[50]	DKA	10.2	Low	All ab negative	Stayed on insulin
Talib et al[51]	DKA	7.9	Low	GADA+
Gunjur et al[52]	DKA	6.9	Low	GADA+, ICA+	Stayed on insulin
Singh et al[53]	DKA			GADA+	Stayed on insulin
Akopyan et al[54]	DKA			All ab negative	Stayed on insulin
Zagouras et al[55]	Hyperglycemia	5.7	Low	GADA+	Stayed on insulin
Kethireddy et al[56]	T1DM	9		GADA+	Stayed on insulin

NSCLC: Non-small cell lung cancer; SCC: Squamous cell carcinoma; DKA: Diabetic ketoacidosis; GADA: Glutamic acid decarboxylase antibody; IA-2: Islet antibody; ICA: Islet cell antibodies; IAA: Insulin autoantibodies; ab: Antibodies.