Factors predicting upstaging from clinical N0 to pN2a/N3a in breast cancer patients

Table 3 Uni- and multivariate logistic regression analysis of risk factors associated with upstaging pN2a/pN3a

Factors	Univariate logistic regression analysis to predictive factors of pN2a/pN3a			Multivariate logistic regression analysis to predictive factors of pN2a/pN3a
	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Age (yr) (< 50 vs ≥ 50)	0.863	0.333-2.24	0.76
ER (positive vs negative)	0.66	0.167-2.60	0.55
HER2 (positive vs negative)	0.833	0.954-7.28	0.87
Invasive diameter of the primary site (≤ 20 mm vs > 20 mm)	4.3	1.48-12.50	0.007	3.53	0.963-13.0	0.057
Nuclear grade (1, 2 vs 3)	1.29	0.426-3.393	0.65
Total positive SLNs (1 vs 2 and more)	3.73	1.34-10.40	0.012	3.92	1.01-15.3	0.048
Maximal diameter of metastasis in the SLNs (< 5 mm vs ≥ 5 mm)	21.2	4.68-96.3	< 0.001	15.6	3.08-79.2	< 0.001
SUVmax of primary tumor (< 3.1 vs ≥ 3.1)	0.96	0.351-2.62	0.94
FDG accumulation of axillary lymph nodes (yes vs no)	13	4.32-39.2	< 0.001	4.84	1.29-18.2	0.02

ER: Estrogen receptor; HER2: Human epidermal growth factor receptor 2; SLN: Sentinel lymph node; SUV: Standardized uptake value; FDG: Fluorodeoxyglucose.