Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant

Table 2 Comparison of pretransplant tumor characteristics, locoregional therapy, and posttransplant tumor characteristics between patients with mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma, matched 1:8 for pre- liver transplant factors and explant factors

Variable	Pre-LT factors			Explant factors
	HCC-CC (n = 7)	HCC (n = 56)	P value	HCC (n = 56)	P value
Recipient characteristics
Age, mean ± SD	58.0 ± 6.9	60.3 ± 9.2	0.317	60.8 ± 7.1	0.2892
Male, n (%)	4 (57.1)	41 (73.2)	0.397	4 (57.1)	0.3751
Etiology of liver disease, n (%)			0.192		0.7891
HCV	6 (85.7)	42 (75.0)		41 (73.2)
Alcohol	0	7 (12.5)		3 (5.4)
HBV	0	5 (8.9)		5 (8.9)
NAFLD	1 (14.3)	0		3 (5.4)
Cryptogenic	0	2 (3.6)		4 (7.1)
CTP class, n (%)			0.201		0.5561
A	3 (42.9)	21 (37.5)		29 (51.8)
B	2 (28.6)	30 (53.6)		20 (35.7)
C	2 (28.6)	5 (8.9)		7 (12.5)
Maximum pretransplant AFP, ng/mL	35.3(4.3-357.0)	9.6(1.1-628.0)	0.150	16.5(1.1-6123.0)	0.6683
Radiographic tumor characteristics
Cumulative tumor diameter, cm, n (%)			0.224		0.723t
< 2.1	1 (14.3)	25 (44.6)		11 (19.6)
2.2-5.0	4 (57.1)	23 (41.1)		36 (64.3)
5.1	2 (28.6)	8 (14.3)		9 (16.1)
Neoadjuvant therapy, n (%)			0.085		0.0811
None	0	14 (25.0)		12 (21.4)
TACE	3 (42.9)	22 (39.3)		28 (50.0)
Other	4 (57.1)	20 (35.7)		16 (28.6)
Pathologic tumor characteristics, n (%)
Total necrosis among treated patients, n/total n (%)	3/7 (33.3)	20/42 (47.6)	0.8000	18/44 (40.1)	0.2231
Within Milan criteria	4 (57.1)	39 (69.6)	0.669	35 (62.5)	> 0.9991
Within UCSF criteria	6 (85.7)	49 (87.5)	> 0.999	45 (80.4)	> 0.9991
Median cumulative nodule size			0.224		0.7231
< 2.1	1 (14.3)	25 (44.6)		11 (19.6)
2.2-5.0	4 (57.1)	23 (41.1)		36 (64.3)
> 5.1	2 (28.6)	8 (14.3)		9 (16.1)
Tumor grade, n/total n (%)			0.722		0.2331
1	0	1/36 (2.8)		0
2	4/7 (57.1)	24/36 (66.7)		18/55 (32.7)
3	3/7 (42.9)	11/36 (30.6)		37/55 (67.3)
Microvascular invasion	0	9 (16.1)	0.580	0	0

¹Fisher exact test.

²t-test.

³Mann-Whitney test. Data expressed as mean ± SD or median (interquartile range). CTP: Child-turcotte-pugh; HBV: Hepatitis B virus; HCV: Hepatitis C virus; LT: Liver transplant; NAFLD: Nonalcoholic fatty liver disease; AFP: Alpha-fetoprotein; TACE: Transarterial chemoembolization; UCSF: University of California San Francisco.