Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant

Table 1 Comparison of pretransplant tumor characteristics, locoregional therapy, and posttransplant tumor characteristics between patients with intrahepatic cholangiocarcinoma and hepatocellular carcinoma, matched 1:8 for pre-liver transplant factors and explant factors

Variable	Pre-LT factors			Explant factors
	ICC (n = 8)	HCC (n = 64)	P value	HCC (n = 64)	P value
Recipient characteristics
Age, mean ± SD	59.4 ± 7.6	61.5 ± 8.0	0.489	60.3 ± 8.6	0.7742
Male, n (%)	5 (62.5)	44 (68.8)	0.704	50 (78.1)	0.3821
Etiology of liver disease, n (%)			0.201		0.7451
HCV	6 (75.0)	50 (78.1)		45 (70.3)
Alcohol	0	9 (14.1)		10 (15.6)
HBV	0	1 (1.6)		3 (4.7)
NAFLD	1 (12.5)	2 (3.1)		1 (1.6)
Cryptogenic	1 (12.5)	1 (1.6)		2 (3.1)
Other	0	1 (1.6)		3 (4.7)
CTP class, n (%)			0.168		0.2101
A	7 (87.5)	43 (67.2)		40 (63.5)
B	0	17 (26.6)		19 (30.2)
C	1 (12.5)	4 (6.3)		4 (6.3)
Maximum pretransplant AFP, ng/mL	28.5 (1.60-801.0)	10.8 (1.7-1133.0)	0.324	12.5 (1.3-6123.0)	0.6203
Radiographic tumor characteristics
Cumulative tumor diameter, cm, n (%)			0.072		0.8621
< 2.1	1 (12.5)	21 (32.8)		9 (14.1)
2.2-5.0	4 (50.0)	37 (57.8)		39 (60.9)
> 5.1	3 (37.5)	6 (9.4)		16 (25.0)
Neoadjuvant therapy, n (%)			0.036		0.0161
None	0	21 (32.8)		21 (32.8)
TACE	8 (100.0)	32 (50.0)		29 (45.3)
Other	0	11 (17.2)		14 (21.9)
Pathologic tumor characteristics, n (%)
Total necrosis among treated patients, n/total n (%)	1/8 (12.5)	25/43 (58.1)	0.008	7/43 (16.3)	0.7411
Within Milan criteria	3 (37.5)	52 (81.3)	0.015	35 (54.7)	0.4631
Within UCSF criteria	6 (75.0)	56 (87.5)	0.307	46 (71.9)	> 0.9991
Median cumulative nodule size			0.072		0.8621
< 2.1	1 (12.5)	21 (32.8)		9 (14.1)
2.2-5.0	4 (50.0)	37 (57.8)		39 (60.9)
> 5.1	3 (37.5)	6 (9.4)		16 (25.0)
Tumor grade, n/total n (%)			0.225		0.2141
1	2 (25.0)	28 (43.8)		4 (6.3)
2	4 (50.0)	31 (48.4)		40 (62.5)
3	2 (25.0)	5 (7.8)		20 (31.3)
Microvascular invasion	3 (37.5)	6 (9.4)	0.056	20 (31.3)	0.7411

¹Fisher exact test.

²t-test.

³Mann-Whitney test. Data expressed as mean ± SD or median (interquartile range). CTP: Child-turcotte-pugh; HBV: Hepatitis B virus; HCV: Hepatitis C virus; LT: Liver transplant; NAFLD: Nonalcoholic fatty liver disease; AFP: Alpha-fetoprotein; TACE: Transarterial chemoembolization; UCSF: University of California San Francisco.