Necessity of neutrophil-to-lymphocyte ratio monitoring for hypothyroidism using nivolumab in patients with cancer

Figure 2 Relationship between neutrophil-to-lymphocyte ratio and nivolumab treatment continuity. The median numbers of nivolumab administration in each group with mean neutrophil-to-lymphocyte ratio (NLR) < 3.5, 3.5 to < 5, and ≥ 5 were 11.5 (n = 52), 8 (n = 25), and 4 (n = 27), respectively. The groups with mean NLR < 3.5 and 3.5 to < 5 had significantly higher treatment continuity than those with mean NLR ≥ 5 (hazard ratio [HR] for low tertile compared with high tertile: 0.23; 95% confidence interval [CI]: 0.13-0.41, P < 0.001; HR for middle tertile compared with high tertile: 0.32; 95%CI: 0.17-0.60; P < 0.001).