Retrospective Cohort Study
Copyright ©The Author(s) 2022.
World J Clin Oncol. Jul 24, 2022; 13(7): 630-640
Published online Jul 24, 2022. doi: 10.5306/wjco.v13.i7.630
Table 2 Studies reporting on pancreatic ductal adenocarcinoma prognosis according to carbohydrate antigen 19-9 level or Lewis antigen status
Survival analysis according to CA 19-9 values
Ref.
n
CA 19-9 in U/mL
Survival
Overall median survival in mo
Berger et al[30], 20047Undetectable32
21≤ 3735
4438-20022
57> 20016
Ferrone et al[33], 2006Mean survival time in yr
29< 372.3
82≥ 371.6
Waraya et al[28], 2009Disease-specific survival in mo
23≤ 3730.6
66> 3712.7
Hirakawa et al[29], 2011Median survival in mo
41Normal39.0
84Elevated16.9
Hartwig et al[32], 2011Median survival in mo
232< 3728.0
41837-39923.5
239≥ 40014.5
Turrini et al[40], 2009Median survival in mo
50< 3722
53400-900 (n = 27), > 900 (n = 26)15
Katz et al[34], 2010Median survival in mo
21< 3752.8
78> 3721.2
Kondo et al[35], 2010Preoperative 3-yr survival (%)
32< 3757%
77> 3730%
Hata et al[36], 2012Preoperative median survival in mo
51< 3716.2
218> 3716.4
Bergquist et al[37], 2016Median OS in mo
3666< 3719.1
7140> 3714
Jia et al[38], 2019Median OS in mo
13< 3521
107≥ 3511
Mattiucci et al[25], 2019Median OS in mo
390-5.025
1675.1-37.038
13937.1-100.032
178100.1-353.022
177> 353.120
Kondo et al[26], 2017Median survival in mo
65< 3752.0
84≥ 3723.7
88< 5052.0
61≥ 15020.9
101< 30046.7
48≥ 30018.8
Dong et al[27], 2014Median OS in mo
18< 3721.6
102≥ 3714.2
Kang et al[31], 2007Disease free survival in mo
18< 5022.20
43≥ 5019.31
Kwon et al[14], 2020Median survival in d
408< 37644
779> 37340
Survival analysis according to Lewis antigen status
Luo et al[39], 2017Median survival in mo
682137 CA 19-9 (-)Stage I, II: 16.6 in Lewis (-), 17.6 in Lewis (+)
47 Lewis (-)Stage III, IV: 6.0 in Lewis (-), 7.8 in Lewis (+)
Luo et al[11], 2018Median survival in mo
148219.8% CA 19-9 (-)8.0 in Lewis (-)
8.4% Lewis (-)10.0 in Lewis (+)
Kwon et al[14], 2020Median survival
1187203 CA 19-9 (-)356 d in Lewis (-)
375 Lewis (-)477 d in Lewis (+)