Short term safety of coronavirus disease 2019 vaccines in patients with solid tumors receiving systemic therapy

Table 3 Adverse events associated with coronavirus disease 2019 vaccination in published studies

Ref.	Sample size (n)	Cancer type	Systemic therapy	Vaccines administered	Patients with Grade 3 or worse AE, %	Immune-related AEs	Comment
Oosting et al[23]	544	Solid Tumors	Chemotherapy; Immunotherapy; Chemoimmunotherapy	mRNA-1273 (Moderna)	10/544 (1.8%)	4% in both immunotherapy and chemoimmunotherapy group	Total 4 serious AEs were potentially related to the vaccination
Cavann et al[24]	257	Solid Tumors	Chemotherapy; Immunotherapy; Chemoimmunotherapy; Chemotherapy plus biological therapy; Biologic therapy	PfizerModerna	0/257 (0%)	NA	Approximately 1/3rd of patients reported mild local reactions (pain, erythema) at the injection site
Waissengrin et al[25]	134	Solid Tumors	Immune checkpoint inhibitor; Chemoimmunotherapy	BNT162b2 mRNA vaccine (Pfizer)	0/134 (0%)	Nonattributable to the vaccination	Fatigue (34%), headache (16%), muscle pain (34%)
Di Noia et al[26]	816	Solid Tumors	Chemotherapy; Immunotherapy; Chemoimmunotherapy; Targeted therapy	Pfizer	3.3% after the 1st dose, 1.4% after the second dose	NA	AE occurred in 359 (44%) and 301 (38.3%) patients after the first and second dose, respectively
Shmueli et al[27]	129	Solid Tumors	Chemotherapy; Immunotherapy; Chemoimmunotherapy; Biological Therapy; Hormonal Therapy; Radiotherapy	Pfizer	0/129 (0%)	NA	AE was reported by 39% of patients after the first dose and 58% of patients after the second dose- all mild to moderate in severity
Tamura et al[29]	120	Solid Tumor	Chemotherapy; Immunotherapy; Targeted Therapy; Chemoimmunotherapy	Pfizer Moderna	0/120 (0%); CTCAE was not used	NA	Study limited to patients receiving treatment for lung cancer only. No serious AEs or treatment delay was observed
Kian et al[28]	210	Solid & Non-Solid Tumors	Chemotherapy; Immunotherapy; Chemoimmunotherapy; Biological Therapy; Hormonal Therapy; Radiotherapy; Radio-hormonal; Chemo-biological	Pfizer	0.004% after 1st dose, 1.9% after the second dose	NA	AE occurred in 65 (31%) and 65 (31%) patients after the first and second dose, respectively. Injection site pain was the most common AE after both doses

AEs: Adverse events; NA: Not available.