Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients: Six case reports

Figure 3 Epstein-Barr virus associated smooth muscle tumor liver biopsies for cases 2-4 (HE stain, 200 x). Hematoxylin and eosin-stained tissue sections showed fascicles of well-differentiated spindle cells with pale eosinophilic cytoplasm and blunt-ended, ovoid nuclei with smooth nuclear contours. A, D, G: No significant cytologic atypia or nuclear pleomorphism is appreciated; B, E, H: All three cases show strong, diffuse reactivity for smooth muscle actin, confirming smooth muscle differentiation, confirming smooth muscle tumor lineage; C, F, I: Chromogenic in situ hybridization studies for the Epstein-Barr virus-encoded small RNA confirm the presence of viral genetic material in all three cases.