Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances

doi:10.5306/wjco.v13.i6.448

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World Journal of Clinical Oncology

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World J Clin Oncol. Jun 24, 2022; 13(6): 448-472
Published online Jun 24, 2022. doi: 10.5306/wjco.v13.i6.448

Table 4 Ongoing clinical trials investigating immune checkpoint inhibitor - based clinical trials in the adjuvant and neoadjuvant setting

NCT	Phase	Study drugs	Treatment setting	Endpoint	Estimated End of Trial
NCT03383458	3	NIVOLUMAB vs PLACEBO	Adjuvant	RFS	June 2025
NCT03867084	3	PEMBROLIZUMAB vs PLACEBO	Adjuvant	RFS, OS	June 2025
NCT03847428	3	DURVALUMAB + BEVACIZUMAB vs PLACEBO	Adjuvant	RFS	September 2023
NCT04102098	3	ATEZOLIZUMAB + BEVACIZUMAB vs PLACEBO	Adjuvant	RFS	July 2027
NCT03859128	2/3	TORIPALIMAB vs PLACEBO	Adjuvant	RFS	April 2024
NCT03839550	2	CAMRELIZUMAB + APATINIB	Adjuvant	RFS	February 2023
NCT04418401	2	ANTI-PD1 + DONAFINIB	Adjuvant	RFS	June 2023
NCT03510871	2	NIVOLUMAB + IPILIMUMAB	Neoadjuvant	ORR, downstaging rate	December 2022
NCT04123379	2	NIVOLUMAB + CCR2/5-inhibitor vs NIVOLUMAB +ANTI-IL8	Neoadjuvant	Safety	October 2024
NCT03222076	2	NIVOLUMAB	Neoadjuvant	Safety	September 2022
NCT03682276	1/2	NIVOLUMAB + IPILIMUMAB	Neoadjuvant	Safety, Delay to surgery	September 2022
NCT03383458	1	NIVOLUMAB vs PLACEBO	Adjuvant	RFS	June 2025
NCT04425226	N/A	PEMBROLIZUMAB + LENVATINIB	Neoadjuvant	RFS, ORR	December 2025

NCT: Number of the clinical trial (Clinicaltrials.gov); RFS: Recurrence-free survival; OS: Overall survival; RFS: Recurrence-free survival; ORR: Overall response rate.

Citation: Rallis KS, Makrakis D, Ziogas IA, Tsoulfas G. Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances. World J Clin Oncol 2022; 13(6): 448-472
URL: https://www.wjgnet.com/2218-4333/full/v13/i6/448.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i6.448