Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances

doi:10.5306/wjco.v13.i6.448

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jun 24, 2022; 13(6): 448-472
Published online Jun 24, 2022. doi: 10.5306/wjco.v13.i6.448

Table 2 Ongoing clinical trials investigating combinations of immune checkpoint inhibitors and anti-vascular endothelial growth factors factors

NCT	Phase		Study drugs	Treatment line	Endpoint	Estimated End of Trial
NCT03794440		2/3	SINTILIMAB + BEVACIZUMABBIOSIMILAR	1	OS, ORR	December 2022
NCT03970616		1b/2	DURVALUMAB + TIVOZANIB	1	Safety	August 2022
NCT03973112		2	HLX-10+BEVACIZUMAB BIOSIMILAR	1	ORR	June 2022

NCT: Number of the clinical trial (Clinicaltrials.gov); OS: Overall survival; ORR: Overall response rate.

Citation: Rallis KS, Makrakis D, Ziogas IA, Tsoulfas G. Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances. World J Clin Oncol 2022; 13(6): 448-472
URL: https://www.wjgnet.com/2218-4333/full/v13/i6/448.htm
DOI: https://dx.doi.org/10.5306/wjco.v13.i6.448